Senior Principal Biological Scientist (Computational Biology)

Job Description

Role: Senior Principal Biological Scientist

Location: South San Francisco , CA

Duration: 12+ Months Contract

Candidates should have their PhD (or equivalent) in a quantitative discipline (e.g., Computational Biology, Computer Science, Machine Learning, Mathematics, Statistics, Physics) or in a biological field (e.g., Oncology, Immunology, Molecular Biology) with demonstrated computational fluency.

We are seeking a visionary Senior Principal Scientist who will lead complex, cross-functional scientific initiatives that bridge cutting-edge AI capabilities and real-world biological applications. This opportunity is ideal for a leader with a record of scientific excellence, cross-disciplinary fluency, and deep translational curiosity.

You’ll work in close partnership with: -

BRAID (Biology Research AI Development), our internal AI model development team

- Computational Biology & Medicine (CBM) and therapeutic area scientists

- Experimental and data-generating partners across Genentech R&D (i.e. Research, Translational Medicine, Cellular & Tissue Genomics etc).

In this opportunity, you will:

- Lead a small team that focuses on high-impact projects that apply and adapt AI models to translational challenges in disease biology, biomarker discovery, and target exploration.

- Frame biological problems in computational terms and design solutions that are biologically meaningful, interpretable, and experimentally testable.

- Collaborate with BRAID to guide model application, validation, and refinement.

- Partner with experimental and clinical teams to ensure scientific questions are addressed with computational rigor and domain awareness.

- Act as a recognized scientific thought leader and strategic contributor to decisions that shape the direction of Genentech’s discovery and translational pipeline.