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<h3>Job Description</h3>
We are looking for a Computational Scientist (Biology) who works at the intersection of high-dimensional biological data, cell biology, and ML. You’ll help build predictive models from high-content imaging and functional biochemical assays to better predict human toxicity. The ideal candidate will have experience transforming noisy biological datasets into actionable insights, uncovering novel biological signals related to drug safety, and performing error analyses on ML models to understand biological mechanisms.
 
Culture:
<ul>
<li>High-agency, high-intensity: They want people who see what matters and do it—no handholding, lots of initiative.</li>
<li>Obsessive and irrational ambition: They admire candidates who could be in big tech but choose a harder path because they want meaning, challenge, and impact.</li>
<li>Craft-first mentality: Deep mastery of your field—biologists who code, engineers who care about biology. You need to love the work itself.</li>
<li>Curiosity-driven: They value people who dig into weird, niche hobbies and demonstrate intense curiosity across disciplines.</li>
<li>Founding mindset: Think like an owner. They're building something from scratch and want people who act like it's theirs.</li>
<li>Not for coasters: If you're looking for stability, predictability, or a 9–5 box-checker job, this isn't it.</li>
</ul>
 
Core technical responsibilities include:
<ul>
<li>Analyze and interpret large-scale multimodal toxicity datasets.</li>
<li>Develop custom algorithms to extract signals from high-content imaging, including Cell Painting and cell morphology data.</li>
<li>Design and optimize novel assays that generate scalable, predictive datasets.</li>
<li>Perform rigorous statistical analyses (curve fitting, dimensionality reduction, modeling, traditional imaging algorithms).</li>
<li>Collaborate with ML researchers to enhance predictive accuracy by integrating biological insights and experimental data.</li>
<li>Implement and manage quality control pipelines for high-throughput, imaging-based screens.</li>
</ul>
 
Preferred technical stack and experience:
<ul>
<li>Python (Pandas, NumPy), Jupyter Notebooks</li>
<li>Image analysis tools like CellProfiler and Cellpose</li>
<li>Deep experience in assay development, high-throughput screening, and automation</li>
<li>Experience analyzing imaging-based phenotypic screens or cell painting datasets</li>
<li>Strong understanding of biology across systems (e.g., liver, heart, kidney, immune)</li>
<li>Demonstrated ability to bridge wet lab protocols and machine learning pipelines</li>
</ul>
 
The right candidate is likely a biologist who taught themselves to code to handle their own data, with a passion for both technical rigor and biological discovery.

Founding Computational Scientist (Biologist)

<h3>Job Description</h3>
Siro Diagnostics, Inc. is seeking a talented, enthusiastic, and highly motivated contract Research Associate I, Assay Development to join the R&amp;D team and help the development of cartridge-based molecular assays. An emphasis will be placed on new amplification chemistries such as isothermal nucleic acid amplification schemes. The ideal candidate needs to have hands-on lab experience, good organizational skills, display a proactive attitude and be flexible about their activities.
 
Please note: This is a contract position, expected to be 40 hours per week. The initial contract term is 3 months. While we cannot guarantee future employment, this role may lead to a full-time opportunity depending on company needs and priorities.
 
Position Responsibilities:
<ul>
<li>Support the optimization of novel isothermal nucleic acid amplification techniques.</li>
<li>Assist the development of nucleic acid detection by conducting experiments through system-level cartridge testing. Testing will be involved in all stages of product development from early assay discovery to verification and validation study execution.</li>
<li>Conduct experiments with live pathogens and human clinical samples in a biosafety level 2 lab.</li>
<li>Troubleshoot problems and identify solutions to technical challenges.</li>
</ul>
 
Desired Skills:
<ul>
<li>0-2 years of experience in a lab setting.</li>
<li>B.S. or M.S. degree in chemistry, biochemistry, molecular biology or a related discipline.</li>
<li>Basic understanding of molecular biology techniques, relevant software, and data analysis tools.</li>
<li>Common methods for DNA/RNA characterization such as PCR (endpoint, real-time).</li>
<li>Excellent organizational skills, ability to multi-task, and efficient with hands-on laboratory research.</li>
<li>Excellent analytical thinking, troubleshooting, and problem-solving skills.</li>
</ul>
 
Physical Requirements:
<ul>
<li>Remaining in a stationary position, often standing or sitting for prolonged period of time</li>
<li>Repeated motions that may include the wrists, hands and/or fingers</li>
</ul>
 
Pay range:
The pay range for this position is $28-30. Actual compensation within the range will be dependent upon the individual's skills, experience, qualifications and location, and applicable employment laws.
 
We are an Equal Opportunity Employer. All qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.

Research Associate I, Assay Development - Contract Position

<h3>Job Description</h3>
ML Applied Scientist
 
My client is a biotech company using synthetic biology and AI to engineer microbes that convert carbon dioxide into valuable chemicals and materials. Their work focuses on creating sustainable, carbon-negative solutions for industries like fuels, polymers, and specialty chemicals.
 
About the job
Responsibilities
<ul>
<li>Work on in-house protein language models — design, build, test</li>
<li>You will be implementing your own ideas</li>
<li>Work with the lab team to produce the best proteins possible</li>
<li>You will be expected to be deep in the THEORY and Implementation</li>
<li>Not looking to hire any “ML engineers” or “Idea people”</li>
<li>Work with the team on all of the above and more!</li>
</ul>
 
Qualifications
<ul>
<li>PhD/Masters required in Computer Science/Statistics/Machine Learning/Math.</li>
<li>Publication(s) in Math and/or THEORETICAL Machine Learning</li>
<li>Preferred venues: NeurIPS, ICML, ICLR, AISTATS, UAI, JMLR/TMLR, IEEE TIT/PAMI, Annals of Math/Stats</li>
<li>Has led/initiated their own research processes and is comfortable in a fast-paced environment.</li>
<li>Must know how to code well</li>
<li>Strong math background.</li>
<li>My client is an early-stage startup, and things will break. They are looking for someone who is willing to roll up their sleeves and fix things.</li>
</ul>
 
 
Benefits
<ul>
<li>Competitive base pay + equity options (0.5-1.5%).</li>
<li>Full health and dental covered</li>
<li>Based in SF, can cover relocation costs</li>
</ul>

ML Research Scientist

<h3>Job Description</h3>
Scientist, Biomarker Assays &amp; Histology Core, Translational Research
W2 Contract-to-Hire
Salary Range: $104,000 - $145,600 per year
Location: Redwood City, CA - Onsite Role
Job Summary:
As a member of the Translational Sciences team Biomarker Assays and Histology Core, you will be accountable for developing and supporting novel immunofluorescence and histology biomarker assays for RVMD RAS(ON) inhibitors.
 
Duties and Responsibilities:
<ul>
<li>Onboard new technology capabilities.</li>
<li>Design and manage experiments in-house related to developing novel biomarker assays for oncology pathway inhibitors.</li>
<li>Analyze and report biomarker data at internal forums.</li>
<li>Evaluate new technologies related to biomarker assays.</li>
<li>Develop high-quality protocols and optimize experimental workflows and data outputs to maximize efficiency.</li>
<li>Keep robust documentation of performed experiments.</li>
<li>Comply with internal standard operating procedures and other quality criteria, where necessary. Collaborate extensively within the team and cross-functionally.</li>
</ul>
 
Requirements and Qualifications:
<ul>
<li>M.S. in Cancer Biology/Molecular Biology or a related field with 3+ years of industry experience</li>
<li>Extensive assay development and execution experience in IHC and/or mIF</li>
<li>Results-oriented with a strong track record of research productivity, as evidenced by impactful contributions to drug candidate projects and/or high-quality publications.</li>
<li>In-depth understanding of Oncology preclinical disease models and relevant signaling pathways</li>
<li>Rigorous, quantitative and detail-oriented</li>
<li>Thrives in a collaborative team setting and is driven by a desire to innovate and contribute in a high-energy start-up environment.</li>
<li>Excellent written and verbal communication skills.</li>
<li>Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute goals as a member of an interdisciplinary team</li>
</ul>
 
Preferred Qualifications:
<ul>
<li>Ph.D. in Molecular Biology/Cancer Biology or related field</li>
<li>Experience in spatial transcriptomics and/or pathology experience is a plus</li>
<li>An understanding of preclinical to clinical translational concepts is preferred</li>
</ul>
 
Desired Skills and Experience
Molecular Biology, assay development, oncology, preclinical, spatial transcriptomics, pathology, immunofluorescence, histology biomarker assays
 
 
Bayside Solutions, Inc. is not able to sponsor any candidates at this time. Additionally, candidates for this position must qualify as a W2 candidate.
 
Bayside Solutions, Inc. may collect your personal information during the position application process. Please reference Bayside Solutions, Inc.'s CCPA Privacy Policy at <a href="http://www.baysidesolutions.com" target="_blank">www.baysidesolutions.com</a>.

Scientist, Biomarker Assays & Histology Core, Translational Research

<h3>Job Description</h3>
Senior Scientist – Antibody Analytical Characterization (Mass Spectrometry)
The heart of Prellis Bio’s strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and next gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids enabling the rapid &amp; diverse discovery of human antibody therapeutic candidates for a range of applications. To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.
We are looking for an accomplished and detail-oriented Senior Scientist with strong expertise in mass spectrometry (MS) and aggregation analysis to join our Antibody Engineering team. This individual will lead the design and execution of analytical strategies focused on the biophysical characterization of therapeutic antibodies, emphasizing mass spectrometry and analytical size-exclusion chromatography (aSEC).
 
Key Responsibilities
<ul>
<li>Lead mass spectrometry-based characterization of therapeutic proteins including monoclonal antibodies, bispecifics, and antigens:</li>
<li>Perform intact mass and subunit analysis</li>
<li>Execute peptide mapping and sequence confirmation</li>
<li>Profile post-translational modifications (e.g., glycosylation, oxidation, deamidation)</li>
<li>Develop, optimize, and troubleshoot aSEC methods to assess aggregation, purity, and product quality.</li>
<li>Characterize high molecular weight aggregates, fragments, and other product- or process-related impurities.</li>
<li>Collaborate closely with Antibody Discovery, Immunogen Design, and Target Biology teams to integrate analytical insights into therapeutic development.</li>
<li>Prepare high-quality technical documentation, including protocols, reports, and SOPs.</li>
</ul>
 
 
Qualifications
<ul>
<li>Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline with 3+ years of relevant industry experience;</li>
<li>– or M.S. with 8+ years,</li>
<li>– or B.S. with 10+ years in biopharmaceutical analytical development.</li>
<li>Proven hands-on expertise in LC-MS/MS, intact mass analysis, peptide mapping, and PTM characterization of antibody-based therapeutics.</li>
<li>Strong experience with aSEC for aggregation analysis, including method development and troubleshooting.</li>
<li>Familiarity with additional chromatographic techniques such as RP-HPLC, HIC, and IEX.</li>
<li>Solid skills in data analysis, interpretation, and scientific communication (both written and verbal).</li>
</ul>
About Prellis Biologics
At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before. Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, &amp; Avidity Partners.
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Prellis offers compelling benefits based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
<ul>
<li>A competitive employee benefits package, including group medical, dental and vision coverage, life and disability insurance, flexible spending accounts an a 401(k) plan</li>
<li>Stock-based long term incentives</li>
<li>Bonus plan</li>
<li>Holiday package including a 1+ week winter shutdown</li>
<li>Flexible work models, including remote and hybrid working arrangements, where possible</li>
</ul>
 
Application deadline
Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
 
We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.

Sr. Scientist-Antibody Analytical Characterization

<h3>Job Description</h3>
Research Associate, Cell Biology
 
Company Overview
XDemics, a Caltech spinout, is fundamentally improving the way cells are grown. We’ve addressed a primary bottleneck—the basic inability to efficiently transfer oxygen in media during cell growth.&nbsp;&nbsp;Our high-density cell respiration (HDCR) technology enables mammalian cells to grow at 20- to 100-fold higher densities—whether in a Petri dish or bioreactor. As a result, scientists and manufacturers can produce more high-quality, viable cells in far less space and time, dramatically slashing R&amp;D and manufacturing costs.
 
From the lab bench to industrial-scale production, HDCR is transformative. One Expansify™ Petri dish replaces 25 traditional polystyrene dishes, vastly accelerating biomedical innovation while cutting costs. With predictable process scale-up, our Profusion-Midi™ 5L and Profusion-Max™ 50L bioreactors will respectively generate up to 1–10 trillion cells, eliminating the need for massive, complicated 200–2000L stirred-tank vessels.
 
HDCR systems deliver high-quality cell and gene therapies more efficiently, reducing the overall cost of these advanced medicines by up to 80%, achieving cost parity with biologics and making these life-changing treatments more accessible worldwide.
 
We are seeking a talented and experienced associate to join our outstanding team in our laboratory facilities within the world-famous Buck Institute in Marin County, California.
 
Position Summary
We are looking for a Research Associate with demonstrated biotech experience in tissue culture, protein expression, and screening. The ideal candidate thrives at the bench, excels in collaboration, and is eager to contribute to a dynamic, cutting-edge high-tech startup environment.
 
Key Responsibilities
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Evaluate the performance of our Expansify™ cultureware product line.
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Perform routine cell culture expansion, characterization, and maintenance of primary and immortalized cell lines.
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Characterize engineered cell lines for mAb and virus production, as well as other applications.
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Conduct molecular biology experiments, including cloning, PCR, qPCR, and sequencing.
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Analyze and interpret experimental data, maintaining accurate and detailed lab records.
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Operate bioreactors
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Maintain laboratory stocks and supplies.
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Collaborate with Engineering Dept. to support ongoing research projects and initiatives.
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Troubleshoot and resolve technical issues.
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Stay current with scientific literature and advancements in the field to implement best practices and innovative techniques.
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Prepare technical reports, presentations, and publications to communicate research findings.
Qualifications
<ul>
<li>BS or MS degree in cell biology, molecular biology, biochemistry, bioengineering or a related field is required.&nbsp;&nbsp;</li>
<li>Minimum of 3 years of hands-on experience in a biotech or pharmaceutical setting is required (startup experience a plus).&nbsp;&nbsp;</li>
<li>Proven expertise in mammalian cell culture, transient expression and purification, and molecular biology techniques (e.g., qPCR, Western blot, cloning) is required.</li>
<li>Strong problem-solving skills and ability to work independently and collaboratively in a fast-paced environment.&nbsp;&nbsp;</li>
<li>Prior experience with primary immune cells, gene therapy or viral vector research is highly desirable.</li>
<li>Strong molecular biology skills, including cloning, PCR, qPCR, and sequencing.</li>
<li>Excellent analytical and problem-solving skills with the ability to troubleshoot complex issues.</li>
<li>Strong organizational and documentation skills, with attention to detail.</li>
<li>Ability to work independently as well as collaboratively within a team environment.</li>
<li>Excellent communication skills, both written and verbal.</li>
</ul>
 
Why Join Us?
At XDemics, you'll be part of a passionate team pushing the boundaries of science in a dynamic, startup environment. We offer competitive compensation, equity opportunities, comprehensive benefits, and the chance to make a real impact in the biotech industry.
 
Equal Opportunity Employer
XDemics is an equal opportunity employer.&nbsp;&nbsp;&nbsp;We are committed to creating an inclusive environment for all employees.

Research Associate

<h3>Job Description</h3>
About Enlaza Therapeutics
Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a disruptive new class of biologic therapeutics. We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.
 
Role Description:
We seek a leader in the field with extensive experience in engineering and optimization of hit molecules to direct and oversee the protein engineering group. The successful candidate will have a deep understanding of structure-function relationships and integrate protein sciences with biological mechanisms to design and execute on discovery campaigns. They will demonstrate exquisite communication and collaboration and will work closely with empirical and computational protein engineering staff and will be a key scientific partner for multiple project and functional leads. 
 
Responsibilities:
<ul>
<li>Use subject-matter expertise in protein engineering to advise teams on therapeutic formatting, target structure-function hypotheses, and design and selection of tool molecules and reagents</li>
</ul>
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Directly supervise protein engineering scientists, providing technical oversight and professional development
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Act as project team lead for discovery programs and ensure delivery of key project goals and milestones
<ul>
<li>Closely collaborate and coordinate with inter-disciplinary discovery and development function leads, scientists and project management to progress molecules from initial hits to developable clinical candidates</li>
</ul>
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Oversee or perform design and construction of antibody/protein combinatorial libraries and engineering campaigns
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Lead continuous improvement in laboratory workflows
<ul>
<li>Supervise the collection, aggregation and curation of experimental and theoretical data to inform predictive algorithms</li>
<li>Assist scientific leadership with technology development and strategy</li>
</ul>
 
Required Skills and Experience:
<ul>
<li>Advanced degree (MS, PhD) in Biochemistry, Chemistry, or other relevant discipline and 7+ years of directly related biopharmaceutical industry experience</li>
<li>Deep knowledge of protein structure, interactions, and physicochemical properties</li>
</ul>
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Experience directly managing scientists 
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Competence in leading cross-functional project teams from target validation, through discovery and optimization, to development candidate
<ul>
<li>Advanced understanding of sequence and structure features and properties of multiple antibody formats (traditional mAbs, bi/multi-specifics, scFvs, single domain antibodies, and others)</li>
<li>Extensive hands-on experience with therapeutic protein and antibody engineering, humanization, liability removal, and optimization </li>
<li>Background in leveraging developability assessment (solubility, stability, impact of formulation, manufacturability) to optimize protein design</li>
<li>Familiarity with advanced in silico experiments, computer programming, databases, and machine learning integration in antibody discovery/engineering</li>
</ul>
 
Additional Experience Preferred but Not Required:
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Experience with plate-based assay design and development and high-throughput workflows
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Experience with engineering of small proteins or enzymes 
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Ability to synthesize structural and biophysical data, including epitope mapping, binding kinetics and physicochemical profiling, to inform decision-making
 
Compensation:
In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.
 
Job Type: 
Full-time
 
Annual Salary:
$170,000-190,000
 
Supplemental Pay Types:
Bonus pay
 
Benefits:
<ul>
<li>Health insurance</li>
<li>Dental insurance</li>
<li>Vision insurance</li>
<li>Flexible spending account</li>
<li>Employee assistance program</li>
<li>401(k)</li>
<li>Retirement plan</li>
<li>Life insurance</li>
<li>Relocation assistance</li>
<li>Parental leave</li>
<li>Flexible schedule</li>
<li>Flexible vacation</li>
<li>Year-end winter break</li>
</ul>

Sr. Principal Scientist/Associate Director - Antibody Engineering

<h3>Job Description</h3>
About Nonfiction Laboratories:
Nonfiction Laboratories is a biotechnology startup based in San Francisco, California. We’re a science and invention driven company, developing a new platform for magnetogenetic control over therapeutic proteins. We want to be able to take any therapeutically-useful protein and be able to turn its activity on/off using magnets. By building therapeutics that can be turned on when and where you need the drug, we spare healthy tissue while targeting disease tissue harder. The potential level of impact here is significant and uncommon — treatments that are more safe, precise, and effective, across a wide range of diseases. We want to open up an entirely new modality and field of research.
To pull this off, we need the most talented inventors, engineers, and scientists we can find. Expect lots of hard work, at the bleeding edge of a new field. We love to collaborate with external colleagues, including many excellent academic laboratories. We value our friendly, invention-focused culture. Doing new things is hard! If you are up to the challenge, please consider applying.
The Role:
Nonfiction Laboratories is seeking a talented and motivated candidate to join our team as a Research Associate, focusing on scaling our workflows around building and evaluating our protein engineering libraries. You will play a critical role in industrializing our existing protein engineering workflows, troubleshooting, and generally making our workflows more robust.
Required:
<ul>
<li>Molecular Biology — PCR (including primer design), minipreps, gels and gel extraction, proper pipette technique,&nbsp;E. coli&nbsp;and yeast culture and transformation.</li>
<li>Cloning — Gibson Assembly, Golden Gate. Colony PCR. Ability to interpret a plasmid map, review a construct description, and select the primers, gene fragment sequence, and protocol to build the desired construct.</li>
<li>Experience using and maintaining an electronic lab notebook (ELN) to track tasks, inventory status, and periodic project updates.</li>
<li>Ability to work on-site in our laboratory in San Francisco.</li>
</ul>
Nice to have:
<ul>
<li>Experience running ELISAs, with the ability to troubleshoot. Bonus for kinetic and cell-based ELISAs.</li>
<li>Experience independently planning library diversification protocols (e.g., site-directed mutagenesis, linker screens, transposase libraries).</li>
<li>Familiarity with fluorescent microscopy.</li>
<li>Sequencing prep.</li>
<li>Experience with protein purification preps.</li>
<li>Experience with mammalian cell culture.</li>
<li>Basic programming skills (Python) for data analysis, primer design, and automation scripting.</li>
</ul>
Equal Opportunity
Nonfiction Labs is an equal opportunity employer. We welcome applicants from all backgrounds and do not discriminate on the basis of race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

<h3>Job Description</h3>
About Enlaza Therapeutics
Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a disruptive new class of biologic therapeutics. We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.
 
Role Description:
We are seeking a highly motivated and skilled analytical development scientist to join our team at our site in San Diego. The successful candidate will leverage their expertise in a range of analytical techniques to support the characterization and development of protein- and antibody-based therapeutics in Enlaza’s covalent biologics platform. The scientist will be responsible for hands-on work to develop, optimize, and execute analytical methods for deployment to support discovery and pre-clinical research through early-stage manufacturing development. They will also provide technical support of analytical development and method transfer and qualification/validation, review of DS/DP release and stability data, and contribute to analytical content in regulatory communications. 
Key Responsibilities:
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Independently design, develop, and optimize analytical methods for release, stability, and characterization of biologics, such as antibodies, ADCs, and bispecifics
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Perform routine physicochemical analytical testing to support biologics drug discovery research and early-stage process development, including HPLC (SEC, HIC, IEX), CE (icIEF, CE-SDS), physical testing (UV-Vis, pH, osmolality), and impurities (HCP)
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Analyze and interpret complex analytical data, identifying trends and correlations to inform project decisions and support process development
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Maintain detailed and accurate records in electronic laboratory notebooks, and author and review technical documents including protocols, reports, and method procedures
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Propose continuous improvement in analytical sciences in alignment with industry advances and trends
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Represent the analytical development function in cross-functional CMC and research project teams
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Contribute to oversight of external analytical development activities, including method development, analytical life cycle management, and stability programs
 
Requirements:
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Advanced degree in analytical chemistry, biochemistry, or closely related field, with 3+ years of industry experience in analytical development for protein-based biopharmaceutical products (equivalent combined education and experience will be considered for the role)
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Subject-matter expertise in analytical separation sciences and proven track record of successful method development and validation
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Demonstrated skill in hands-on operation of modern analytical instruments
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Strong understanding of protein chemistry and degradation pathways
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Comfort operating on a small, dynamic team and open to providing and receiving cross-training opportunities
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Excellent written communication skills
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Previous exposure or participation in authoring regulatory submission content 
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Understanding of early-stage biopharmaceutical development manufacturing unit operations, manufacturing science and technology, and GxP quality control
·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Previous experience with analytical support of process development, formulation, or drug product groups is preferred
 
Compensation:
In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.
 
Job Type: 
Full-time
 
Annual Salary:
$130,000-150,000
 
Supplemental Pay Types:
Bonus pay
 
Benefits:
<ul>
<li>401(k)</li>
<li>Dental insurance</li>
<li>Employee assistance program</li>
<li>Flexible schedule</li>
<li>Flexible spending account</li>
<li>Health insurance</li>
<li>Life insurance</li>
<li>Paid time off</li>
<li>Parental leave</li>
<li>Relocation assistance</li>
<li>Retirement plan</li>
<li>Vision insurance</li>
<li>Year-end shutdown</li>
</ul>

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